p53, which is also known as TP53 or tumor protein,k acts as a tumor suppressor in many types of tumors and plays an important role in cancer development. It works by acting like a checkpoint in the cell cycle to either prevent or start programmed cell death, apoptosis. A disruption in p53 can lead to abnormal cells multiplying. Alterations of the p53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families.
It is strongly suggested that the antibody reactivity be empirically titrated by the end user for optimal performance in the application of interest. ICC: 1:500 - 1:1000